Kingfa Medical Independently Develops Nitrocellulose Membrane, Now in Production.Its consistency and long-term stability have reached international advanced levels, providing new options for immunodiagnostic reagents.

What is an NC Membrane?

The NC membrane (Nitrocellulose membrane) is a white fibrous thermoplastic polymer formed by dissolving nitrocellulose and applying complex process controls during coating and drying. The nitro groups in the molecular chains of the NC membrane exhibit strong electronegativity, enabling excellent nonspecific adsorption capabilities for biomacromolecules such as proteins and nucleic acids. As a result, NC membranes are widely used in immunoassays, protein blotting, and related fields.

Why is High-Quality NC Membrane Production Challenging?

The difficulty in manufacturing high-quality NC membranes lies in controlling the complex phase separation process. As the solvent evaporates, the composition of the nitrocellulose solution continuously changes. Upon reaching a critical point, liquid-liquid phase separation occurs. The cellulose-rich phase gradually gels and solidifies, forming an interconnected skeletal network, while the cellulose-poor phase converts into the rich phase and disappears, ultimately leaving pores.

The phase separation process is influenced by both thermodynamic and kinetic factors, requiring precise control of solution ratios and process conditions to ensure product uniformity and consistency. The extreme manufacturing challenges have led to long-term reliance on imported NC membranes in China, hindering the development of the domestic IVD industry.

What are the Advantages of KINGFA MEDICAL Self-Developed NC Membrane?

Kingfa Medical has improved membrane formulation, processing, and pore structure regulation technologies, enabling its NC membrane to achieve international advanced levels in batch-to-batch consistency and long-term stability while maintaining high detection sensitivity. The launch of this NC membrane will positively impact the immunodiagnostics field, empowering domestic companies to compete more effectively in the global market. This technological breakthrough also showcases Kingfa Medical’s innovation capabilities in critical IVD raw materials, creating new development opportunities for the industry.

Core Product Advantages

High Protein Binding Capacity: The hydrophobic groups on nitrocellulose molecular chains and the enormous specific surface area enable the NC membrane to firmly bind proteins with high binding capacity.

Uniform 3D Microporous Structure: A specialized solvent evaporation-induced phase separation process creates an NC membrane with uniform pore structures across all spatial dimensions, allowing steady and consistent chromatographic flow of liquids.

Surface Treatment Technology: Precise hydrophilic molecule treatment ensures excellent wettability without compromising protein binding, enabling rapid absorption of coating solutions and clear, continuous coating lines.

Thickness and Flow Rate Stability: High-precision metering devices and balanced fluid pressure distribution processes ensure stable thickness and flow rates in both lateral and longitudinal directions.

Batch-to-Batch Consistency: A robust quality management system—including multi-stage inspections of raw materials, intermediates, and finished products, along with strict control of production environment parameters (temperature, humidity, airflow)—guarantees consistency in thickness, pore size, flow rate, and detection signal sensitivity across batches.

Long-Term Stability: Special stabilization technology ensures the NC membrane maintains stable performance during long-term storage and use, safeguarding the reliability of immunochromatographic products throughout their shelf life.

As an innovative breakthrough in the IVD field, Kingfa Medical self-developed NC membrane will debut at CACLP 2025!

Join us at Kingfa Medical booth to explore the future of precision medicine and collaborate in advancing IVD toward greater efficiency and intelligence, injecting new technological momentum into global healthcare.